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For anyone, no background needed. Education, not medical advice.
11M views1 year ago2 recommendations
Evidence and public healthMedicines and supplementsGenetics and genomicsPsychedelicsHistory of medicine
Veritasium tells the story of Nobel laureate Kary Mullis and his invention of the polymerase chain reaction technique.
LSD-fiend, surfer, maverick — Kary Mullis might be the weirdest person ever to win the Nobel Prize. Get a little smarter every day with Brilliant. Visit brilliant.org/veritasium to get 20% off your annual premium subscription. A massive thank you to Tom White, Hudson Freeze, and Henry Erlich for their time and expertise on the subject. A huge thank you to Eleni Kleanthous, Jan Novoselec, Kieran Sparkes, Andrew Garcia, and UCSD’s Pride Lab for reviewing the science. For great coverage of the PCR story, check out ‘Making PCR’ by Paul Rabinow - ve42.co/Rabinow1996 For exclusive behind-the-scenes content on the making of this video, join us on Patreon: patreon.com/posts/119438561 DNA under a microscope Kary Mullis at Berkeley Cetus and early biotech How to detect sickle cell anemia Kary Mullis at Cetus Infinite DNA glitch explained Kary Mullis struggles Thermus Aquaticus to the rescue Going public The quirky genius, Kary Mullis ▀▀▀ Special thanks to our Patreon supporters! Join the community to help us keep our videos free, forever: ve42.co/PatreonDE Adam Foreman, Albert Wenger, Alexander Tamas, Anton Ragin, Autodidactic Studios, Bertrand Serlet, Blake Byers, Bruce, Dave Kircher, David Johnston, Evgeny Skvortsov, Farbod Mansorian, Garrett Mueller, Gnare, gpoly, Greg Scopel, I. H., Juan Benet, KeyWestr, Kyi, Lee Redden, Marinus Kuivenhoven, Matthias Wrobel, Meekay, meg noah, Michael Krugman, Orlando Bassotto, Paul Peijzel, Richard Sundvall, Sam Lutfi, Spilmann Reed, Tj Steyn, TTST, Ubiquity Ventures, and wolfee If you’re looking for a molecular modeling kit, try Snatoms, a kit I invented where the atoms snap together magnetically - ve42.co/SnatomsV ▀▀▀ References: Mullis, K. (1968). Cosmological Significance of Time Reversal. Nature - ve42.co/Mullis1968 Mullis, K. (1997). Dancing Naked in the Mind Field. Vintage - ve42.co/Mullis1997 McDonald, C. (2019). Intolerable Genius. Cal Alumni Association - ve42.co/McDonald2019 Conner, B. J. et al. (1983). Detection of sickle cell beta S-globin allele by hybridization with synthetic oligonucleotides. Proceedings of the National Academy of Sciences - ve42.co/Conner1983 Human Beta-globin gene via UniProt - ve42.co/BetaGlobin Saiki, R. K. et al. (1985). Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia. Science - ve42.co/Saiki1985 Mullis, K. B. (1990). The Unusual Origin of the Polymerase Chain Reaction. Scientific American - ve42.co/Mullis1990 Kary B. Mullis via The Nobel Prize - ve42.co/Nobel1993 Restriction Enzymes via The Nobel Prize - ve42.co/Nobel1978 Saiki, R. K. et al. (1988). Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase. Science - ve42.co/Saiki1988 Smith, T. C. (2024). HIV Denial in the COVID Era. AIDS aWhat people say. Recommended as an exceptionally accessible and engaging history of the invention of PCR and the colorful life of Kary Mullis.
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