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The Evolution of Bacteria on a “Mega-Plate” Petri Dish (Kishony Lab)

Harvard Medical School

338K subscribers • 24 videos on Rounds • Health institution

YouTube
  • Recommended by 6 people, in Hacker News, across 5 different months.
  • May be out of date. Uploaded 10 years ago, in an area where guidance changes.

For anyone, no background needed. Education, not medical advice.

2.9M views10 years ago6 recommendations

Immunity and infectionHow the body worksInfectious diseaseGenetics and genomics

A visual demonstration showing how bacteria mutate and evolve to survive increasingly high doses of antibiotics over eleven days.

In a creative stroke inspired by Hollywood wizardry, scientists from the Kishony Lab at HMS and Technion (www.technion.ac.il/en/) have designed a simple way to observe how bacteria move as they become impervious to drugs. The experiments are thought to provide the first large-scale glimpse of the maneuvers of bacteria as they encounter increasingly higher doses of antibiotics and adapt to survive—and thrive—in them. Read the full story at hms.harvard.edu/news/bugs-film Version that includes an audio description: youtu.be/_aASQd0Hwgw Like Harvard Medical School on Facebook: goo.gl/4dwXyZ Follow on Twitter: goo.gl/GbrmQM Follow on Instagram: goo.gl/s1w4up Follow on LinkedIn: goo.gl/04vRgY Website: hms.harvard.edu

Why it's here

6 people recommend this

What people say. Highly recommended as an incredibly striking and clear visual demonstration of bacterial evolution and antibiotic resistance.

Retricin Hacker News • Recommends

On “Videos of Evolution in Action”

The video shows mutations in real time as bacteria grow or fail to grow in various places. link to this video It's more a demonstration than experiment, but visually it's just really striking.

lossoloin Hacker News • Recommends

On “The Age of the Superbug Is Here”

This is an amazing video1 from Harvard Medical School released couple of days ago showing evolution of bacteria that evolve in 10 days to become resistant to antibiotics. 1 link to this video

sengorkin Hacker News • Recommends

On “How to Avoid a Post-Antibiotic World”

For those that would like to visualise how the bacteria vs anitbiotics evolve in an experiment over 11 days, have a look at this video from Harvard: link to this video

ramgorurin Hacker News • Recommends

On “The man who bottled evolution”

Harvard medical school did a similar experiment on fast evolution of bacterial resistance to antibiotics on a petri-dish. It also clearly shows the lineage of evolution. Very interesting. link to this video

robocatin Hacker News • Recommends

On “Bladder cancer 'attacked and killed by common cold virus'”

> Why do you think the strongest of the strong bacteria are found in hospitals? I presume you mean strong against antibiotics and sterilisation. The evolved bacteria are likely weaker along other dimensions (that are less important for survival in a hospital setting). Some evolution is compromises, improving X has cost Y. Aside: the mega-plate video is an unbelievably good demonstration of bacterial evolution: link to this video especially note the tree at the end showing how many different mutations evolved.

idiocratin Hacker News • Recommends

On “It's 2023 and I still have to touch a piss soaked door handle to exit a bathroom”

Strengthens your immune system. Without exposure (playing in mud, touching other people), we are only weaker. Bio life is really complicated. Sterilization works well only to a certain degree, before becoming damaging, e.g. causing resistance. Somewhat related, here is an interesting visualization of bacteria developing resistance to antibiotics. link to this video

lmilcinin Hacker News • Mentions

On “Pliocene and Eocene provide best analogs for near-future climates”

It is absolutely nowhere near evolutionary adaptive capacity. Life will not end and the world will still be there. Life's evolutionary adaptive capacity is stagerring! Just take a look at the experiment where it barely stretches muscles: link to this video What I understand they mean is "Life as we know it" defined as large animals and familiar plants roughly in places where we are used to seeing them. We are looking at life with our antropocentric point of view and we basically want familiar stuff to stay the same and we don't want unfamiliar stuff to show up. We don't want things to change and that's why potential large shift in how life presents itself may be caulled as "end of the world" event, but…

estebankin Hacker News • Mentions

On “SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility”

The mitigations are effective in slowing the spread (to varying degrees, due to a multitude of factors), which in turn slow down the rate of mutation. In any case, I would expect the dispersion of the virus to follow a pattern similar to link to this video

HPsquaredin Hacker News • Mentions

On “Moore's Law for Everything”

Technological innovation is a balance between diminishing returns (ever-smaller niches getting filled, ever-increasing complexity) and the occasional breakthrough which spawns further development. The visual metaphor of bacteria developing antibiotic resistance in ever-greater levels of the antibiotic, springs to mind: link to this video

woopwoopin Hacker News • Mentions

On “History as Weather”

Non-obvious is necessary to avoid appending "and also the sun rises in the east and sets in the west every day" to every prediction to get it to satisfy the other three. That a fact is observational does not make it non-scientific. I have no problem calling a description of a human cell science. I'd also add that you absolutely do not need 500 years to verify natural selection, see e.g. this video: link to this video

_vertigoin Hacker News • Mentions

On “Vaccination blunts, but does not defeat Delta”

…ospital with an antibacterial solution result in no bacteria or just make it more likely to see resistant bacteria? I’d guess it’s a function of how potent the solution was and how well every last surface was coated. If you start with a 10% solution, don’t achieve full coverage and keep ramping up slowly perhaps we’ll just see something like this: link to this video Agree with the rest of your post though.…

jasodein Hacker News • Mentions

On “DNA seen through the eyes of a coder”

>What are the tests? Tests == adaptation to the environment E.g. short 2 minute video showing how bacteria evolves with random mutations to produce resistance to antibiotics: link to this video Likewise at a macro scale, if Earth's atmosphere becomes inhospitable because of global nuclear war or a big asteroid collision, then the new "test for life" is adapting to the radioactive dust cloud. Keep mutating across generations until survivors can thrive.

taf2in Hacker News • Mentions

On “No antibiotics worked, so this woman turned to phage scientists”

Really I feel like this has been a hot topic for at least 15 years.. for example 5 years ago this link to this video was on hacker news and got a lot of discussion as I recall… Ok maybe you are right my search yielded few posts that got any traction - so maybe it was just me sharing with people I know!

robocatin Hacker News • Mentions

On “A tiny genetic change inflicts old age on young kids”

Aging is one side effect of a major internal system that counteracts cancers. Most of our cells are preprogrammed to die after a certain number of replications. This is one of many systems that counteract normal genetic mutations - which can cause cancers and other side effects. By definition a cancer has to reproduce and one way of defeating cancers is for cells to die (or be killed) once they reach a number of cell reproductions. Think of a binary tree where the tree depth is the number of cell reproductions, and telomere length controls tree depth. Each time a cell reproduces it risks mutations. Stem cells are the progenitor branches, and stem cells maintain “cleaner” copies of DNA, which…

dennis_jeeves1in Hacker News • Mentions

On “Antibiotic that does not evoke bacterial resistance”

>BTW, the "serial dilution" method name sounds to me like what is illustrated by this famous video: link to this video Great video, ( if it's not fictitious)

MontyCarloHallin Hacker News • Mentions

On “CRISPR Tech Selectively Shreds Cancer Cells, Including "Undruggable" Cancers”

>there's no "be a better/stronger cancer and spread more effectively to more hosts" No, but there is "be a better/stronger cancer cell and don't succumb to whatever therapy is killing its neighboring cells." It's exactly akin to how dosing isolated populations of bacteria with antibiotics selects for individual cells that are resistant, which then multiply and dominate 0, just like a tumor. 0 link to this video