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A Look at the Unconscious Brain Under General Anesthesia

NIH VideoCast

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  • Published by NIH VideoCast, one of the health institutions Rounds lists. Nobody has recommended it in the communities yet, so it ranks below community picks.
  • May be out of date. Uploaded 15 years ago, in an area where guidance changes.

Aimed at clinicians, students or researchers. Education, not medical advice.

28K views15 years ago

Brain and nervesMedicines and supplementsNeuroscienceHow drugs workPhysiology

An exploration of the neurophysiological and neuroanatomical mechanisms of general anesthesia-induced loss of consciousness in humans.

Air date: Wednesday, March 02, 2011, PM Time displayed is Eastern Time, Washington DC Local Category: Wednesday Afternoon Lectures Description: General anesthesia is a drug-induced, reversible condition comprised of five behavioral and physiological states: unconsciousness, amnesia (loss of memory), analgesia (loss of pain sensation), akinesia (immobility), and cardiovascular, respiratory and thermoregulatory stability with control of the stress response. The mechanisms by which anesthetic drugs induce the state of general anesthesia is considered one of the biggest mysteries of modern medicine. We have been using three experimental paradigms to study general anesthesia-induced loss of consciousness in humans: combined fMRI/EEG recordings, high-density EEG recordings and intracranial recordings. These studies are allowing us to establish precise neurophysiological, neuroanatomical and behavioral correlates of general anesthesia. We will discuss the relation between our findings and two other important altered states of arousal: sleep and coma. Our findings suggest that the state of general anesthesia is not as mysterious as currently believed. The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. Author: Dr. Emery Brown, Massachusetts Institute of Technology Runtime: Permanent link: videocast.nih.gov/launch.asp?16502

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NIH VideoCast is on Rounds' list of health institutions, and this upload is one of its most-watched lectures or explainers. Nobody has recommended it in the communities yet, so it ranks below community picks.