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Michael Hall (University of Basel): The Story of TOR (Target of Rapamycin)

iBiology Science Stories

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  • Published by iBiology Science Stories, one of the health institutions Rounds lists. Nobody has recommended it in the communities yet, so it ranks below community picks.
  • Presented by Michael Hall, Professor of Biochemistry at the University of Basel, as the video describes them
  • May be out of date. Uploaded 9 years ago, in an area where guidance changes.

Assumes interest and some biology. Education, not medical advice.

35K views9 years ago

Aging and longevityHeart and metabolismBiology of agingCells and moleculesLongevity interventions

Michael Hall describes how investigating the drug rapamycin in yeast led to the discovery of TOR, a central controller of cell growth.

ibiology.org/cell-biology/target-rapamycin/ Michael Hall describes the discovery of TOR (Target of Rapamycin) protein, the key controller of the size of both individual cells and entire organisms.   Talk Overview: TOR, the Target of Rapamycin, is now known to be a central controller of cell, tissue and organism growth and an important molecule in many human diseases including cancer, cardiac hypertrophy, diabetes and obesity.  Michael Hall explains how the fortuitous decision, in 1991, to investigate the action of rapamycin in yeast, led to the discovery of TOR. Speaker Biography: Dr. Michael Hall received his PhD from Harvard and was a post-doctoral fellow at the Institut Pasteur and the University of California, San Francisco.  He joined the Biozentrum of the University of Basel in 1987 and where he is currently a Professor of Biochemistry. Hall’s lab continues to study TOR and its role in development, aging and disease. Hall has received numerous awards in recognition of his pioneering work.  Recent honors include the Louis-Jeantet Prize for Medicine (2009), the Marcel Benoist Prize (2012), the Breakthrough Prize (2014), the Canada Gairdner Award (2015), and the Albert Lasker Basic Medical Research Award (2017).  Hall is also a member of the US National Academy of Sciences. Learn more about Dr. Hall’s research here: biozentrum.unibas.ch/research/groups-platforms/overview/unit…

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