Skip to content
0:00 / 0:00

Jack Szostak (Harvard/HHMI) Part 1: The Origin of Cellular Life on Earth

Science Communication Lab

194K subscribers • 2 videos on Rounds

YouTube
  • Recommended by 6 people, in Hacker News, across 6 different months.
  • Presented by Jack Szostak, as the video describes them

Assumes interest and some biology. Education, not medical advice.

378K views14 years ago6 recommendations

How the body worksCells and moleculesGenetics and genomics

Jack Szostak explores how simple chemical molecules on early Earth could have spontaneously formed the first self-replicating protocells.

ibiology.org/evolution/origin-of-life/ Szostak begins his lecture with examples of the extreme environments in which life exists on Earth. He postulates that given the large number of earth-like planets orbiting sun-like stars, and the ability of microbial life to exist in a wide range of environments, it is probable that an environment that could support life exists somewhere in our galaxy. However, whether or not life does exist elsewhere, depends on the answer to the question of how difficult it is for life to arise from the chemistry of the early planets. Szostak proceeds to demonstrate that by starting with simple molecules and conditions found on the early earth, it may in fact be possible to generate a primitive, self-replicating protocell.

Why it's here

6 people recommend this

What people say. Highly recommended as an engaging and accessible lecture series explaining the chemical origins of life and the RNA world hypothesis.

lawpoopin Hacker News • Recommends

On “Luca, the Ancestor of All Living Things”

I personally am a fan of the RNA world hypothesis: link RNA can act as both a store of information, and as an enzyme catalyzing reactions. In this theory, certain sequences of RNA would be the original self-replicating molecules. Over time, variations in their replication would give rise to other enzymes for specialized reactions, and DNA as a pure-data store. Jack Szostak has done an excellent series of short videos on the theory, and he and his students have done a surprising amount of experiments to support the theory. link to this video

21in Hacker News • Recommends

On “Life”

Recently I got interested in the origin of life. I found this 3 part talk which discusses how the simplest possible life form might have looked like. My feeling after watching this is that we are slowly getting there (which will also mean jump starting in a dish a self replicating thing from inorganic matter). link to this video link link

chr1in Hacker News • Recommends

On “‘Minimal’ cell raises stakes in race to harness synthetic life (2016)”

There are also people trying to assemble life from simpler molecules that are commonly formed in non-organic processes. This series of presentation by Jack Szostak is rather interesting link to this video

trevynin Hacker News • Recommends

On “New physics needed to probe the origins of life”

Jack Szostak does a pretty good job of outlining how life might have arisen. It’s less mysterious than it intuitively might seem: link to this video link

martythemaniakin Hacker News • Recommends

On “Cellular Automata in the Browser”

I found it cute and quite meaningful. If you spend a good deal of time on Cellular Automata, Dissipative Structures and genetics these things really start to jump out at you. Here's a starter pack: Cellular Automata and Computation: link Origin of Life: link to this video Dissipative Structures: link

lovecgin Hacker News • Recommends

On “Time-lapse of a single cell transforming into a salamander (2019)”

There are some plausible theories, like RNA randomly crystallizing on a suitable surface. Sooner or later a self-copying one just happened to crystallize by chance, and there was no going back. Fun lecture series: link to this video

martythemaniakin Hacker News • Mentions

On “What's a virus, anyway? The bare-bones basics”

Look into "dissipative structures", which are indeed closely linked to thermodynamics. In short, energy gradients (ie, on hydrothermal vents) can cause matter to organize itself into structures that more efficiently dissipate this energy. You can see how the creation of this structure would in turn enable the creation of a new kind of structure that lives on top of that. link link to this video