u/zenarcade3Psychiatrist (Verified)in r/Psychiatry • Recommends
Nice recap of the paper that led to the black box warning for anti-depressants for increased risk of suicidality
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1.4K views2 years ago1 recommendation
Medicines and supplementsMental healthHow drugs workDepression and anxiety
Greg Malzberg, MD, reviews the clinical evidence and history behind the FDA black box warning for antidepressant-induced suicidality in children.
In this video, we explore the sensitive topic of the link between antidepressants and suicidal thoughts in kids and understand the complex relationship between suicidality and anti-depressants in kids. 💡Anti-depressant Course: psycho.farm/antidepressant-course ================ 1 Page Summary of Paper: drive.google.com/file/d/1d_63fjSFTW2hm7rZ0HFcg7fxTfXX8cTW/vi… Paper: pubmed.ncbi.nlm.nih.gov/16520440/ ================ Follow PsychoFarm: 🔴SUBSCRIBE ► youtube.com/c/Psychofarm?sub_confirmation=1 🧠Mental Health Resources: psycho.farm/services-4 ➡️Instagram: instagram.com/thepsychofarm/ ➡️Tiktok: tiktok.com/@thepsychofarm ➡️Twitter: twitter.com/ThePsychoFARM ================ The video delves into the presence of black box warnings on FDA labels for antidepressants, specifically addressing increased risks of Antidepressant Suicidal Thoughts and behaviors, particularly in children and young adults. It highlights age-dependent patterns, with increased risks under 25, neutral effects for ages 25-64, and reduced risks for those over 65. The transcript explores a paper that led to these warnings, detailing investigations into antidepressant-induced Suicidality and Anti-depressants in pediatric patients. It reveals findings from over 4,000 patients across 24 trials, noting no completed suicides but an increased risk of suicidal ideation and behavior associated with Anti-depressants in kids, though the absolute risk remains small. The video emphasizes that while antidepressants weren't linked to completed suicides, there was a concern over increased suicidality, leading to FDA warnings. It also discusses reasons behind this increased risk, including improvements in psychomotor symptoms before mood symptoms, potential undiagnosed bipolar disorder, and psychological factors. Despite concerns, organizations like the American Academy of Child and Adolescent Psychiatry maintain that the overall risk-benefit ratio for SSRIs is favorable with careful monitoring. The black box warnings aimed to increase monitoring but resulted in decreased prescriptions and heightened parental hesitations. The video encourages further exploration into the complexities of Suicidal Thoughts in Kids and antidepressant use. The relationship between antidepressants and suicide risk, particularly in children and adolescents, has been a topic of significant concern and investigation. Studies have explored whether SSRIs, a common class of antidepressants, may be associated with an increased risk of suicidal thoughts or behaviors in young patients. The use of antidepressants in children and adolescents has raised questions about their potential to exacerbate suicidality, prompting careful monitoring and consideration by healthcare professionals. While antidepressants are commonly prescribed to alleviate symptoms of depression and other mood disorders, concerns about their safety in vulnerWhat people say. Clinicians recommend this video as a nice recap of the paper that led to the FDA black box warning.
u/zenarcade3Psychiatrist (Verified)in r/Psychiatry • Recommends