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Bret Weinstein on "The Portal" (w/ host Eric Weinstein), Ep. #019 - The Prediction and the DISC.

Eric Weinstein

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  • Recommended by 5 people, in Hacker News, across 6 different months.
  • Presented by Bret Weinstein, as the video describes them
  • Debated among experts. Its central claim is contested, so look for the other side.

Assumes interest and some biology. Education, not medical advice.

704K views6 years ago5 recommendations

Aging and longevityEvidence and public healthBiology of agingCancer biologyGenetics and genomics

Bret Weinstein discusses how breeding protocols altered lab mice telomeres, impacting research on aging and cancer.

All of our Mice are Broken. On this episode of The Portal, Bret and Eric sit down alone with each other for the first time in public. There was no plan. There was however, a remarkable story of science at its both best and worst that had not been told in years. After an initial tussle, we dusted off the cobwebs and decided to reconstruct it raw and share it with you, our Portal audience, for the first time. I don't think it will be the last as we are now again looking for our old notes to tighten it up for the next telling. We hope you find it interesting, and that it inspires you younger and less established scientists to tell your stories using this new medium of long form podcasting. We hope the next place you hear this story will be in a biology department seminar room in perhaps Cambridge, Chicago, Princeton, the Bay Area or elsewhere. Until then, be well and have a listen to this initial and raw version. [The DISC referred to in the Title is the Distributed Idea Suppression Complex as discussed on episode #018 of The Portal Podcast.] Original Audio Only Sponsors: Quip: Getquip.com/portal Wine Access: Wineaccess.com/portal Indeed: Indeed.com/portal Blinkist: Blinkist.com/portal

Why it's here

5 people recommend this

What people say. Recommended for its detailed discussion on how lab mice breeding protocols may have compromised safety testing and aging research.

meowfacein Hacker News • Recommends

On “The Wolfram Physics Project”

…most mice used by US researchers are broken" and "most tests done on mice by US researchers are flawed because of it" are likely also true. I have no idea if the above claims are true, of course, but they should be investigated on their merits. Bret Weinstein's 2002 paper: link The podcast between Eric and Bret Weinstein covering the full story: link to this video Not sure if you already listened to the podcast, but if you haven't, I'd recommend listening to all of it.…

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On “Cracking down on research fraud”

They go over multiple topics. Check the top comment for timestamps. If you want to hear the full story I suggest listening to this podcast episode: link to this video . It's long, but I found it very interesting.

bz33tin Hacker News • Recommends

On “Lab mice have a chill, and that may be messing up study results (2016)”

According to Bret Weinstein who figured out the connection between telomere length and breeding, they seem to have quietly changed the breeding protocols to bring the telomere length back down to be in line with wild type mice. He talks about it in a long interview that gets really interesting about a hour in: link to this video

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On “Bodybuilding supplement promotes healthy aging and extends life span in mice”

Uh oh, mice in labs are not like humans in this regard at all. Lab Mice have extraordinary cell repair capabilities. My guess is that the AKG slows down cell division. This podcast delves into the problem with lab mice and explains the trade offs that happen on an evolutionary and cellular level in mice with regards to longevity. link to this video

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On “Is aging inevitable?”

The answer is yes. It seems the author is reasoning more in the philosophic realm than in evolutionary biology. In this podcast 1 an evolutionary biologist goes into depth about telomeres, evolution and how cancer and longevity are two sides of the same coin. Long story short, having cells die after a number of replications is a postive trade off. It means that when a cell replicates too fast it also dies fast. The opposite are cancer cells, which replicate too fast and don't die. 1 link to this video

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On “Slowed canonical progress in large fields of science”

I recommend the book: Rigor Mortis: How Sloppy Science Creates Worthless Cures, Crushes Hope, and Wastes Billions Generally, all scientific fields have immense issues related to the walled gardens and limitations created by their peers. I also recommend this discussion between Eric and Brett Weinstein which highlights just one example of the major issues: link to this video

sradmanin Hacker News • Mentions

On “The Problem with America’s Lab Mice [video]”

The publications section on Bret Weinstein’s Wikipedia page 1 lists the paper 23: > Weinstein, Bret S; Ciszek, Deborah (2002). "The reserve-capacity hypothesis: Evolutionary origins and modern implications of the trade-off between tumor-suppression and tissue-repair". Experimental Gerontology. 37 (5): 615–27. There doesn’t seem to be a succinct write up on how this hypothesis led to Carol Greider’s 2009 Nobel Prize 4. Greider did not recognize Weinstein’s contribution 5. 1 link 2 link 3 link 4 link 5 link to this video

jxramosin Hacker News • Mentions

On “AI intensifies fight against ‘paper mills’ that churn out fake research”

There was an interesting claim I heard from Eric Weinstein regarding peer review that he characterized as a cancerous infiltration into all of science from some medical area? Aha, found it in my notes... """ 1:32:28 Eric: but let me jump in--peer review is a cancer from outer space. It came from the biomedical community, it invaded science. The old system, because I have to say this because many people who are now professional scientists have an idea that peer review has always been in our literature and it absolutely mff __ has not. Bret: right Eric: Okay. It used to be that the editor of a journal took responsibility for the quality of the journal which is why we had things like nature…