0:00 / 0:00
The Structural Basis of Ebola Viral Pathogenesis
NIH VideoCast
47K subscribers • 38 videos on Rounds • Health institution
- Published by NIH VideoCast, one of the health institutions Rounds lists. Nobody has recommended it in the communities yet, so it ranks below community picks.
- Presented by Dr. Saphire, as the video describes them
- May be out of date. Uploaded 12 years ago, in an area where guidance changes.
Aimed at clinicians, students or researchers. Education, not medical advice.
23K views12 years ago
Immunity and infectionHow the body worksInfectious diseaseCells and moleculesThe immune system
Dr. Saphire analyzes the structures and functions of Ebola virus proteins to understand viral entry, pathogenesis, and immune evasion.
The Structural Basis of Ebola Viral Pathogenesis Air date: Wednesday, November 06, 2013, PM Description: The Wednesday Afternoon Lecture Series presents the NIH Director's Lecture Dr. Saphire's lab studies viruses with compact genomes that encode just four to seven genes each. Viruses with limited genomes offer a defined landscape of possible protein-protein interactions. Each protein is critical-many are obligated to perform multiple functions and some rearrange their structures to achieve those new functions. As a result, these few polypeptides accomplish a surprisingly complex set of biological functions including immune evasion, receptor recognition, cell entry, transcription, translation, assembly and exit. Dr. Saphire systematically analyzes the structures and functions of each protein encodes by the virus to gain fundamental insights into the biology of entry, immune evasion, and assembly, and to decipher the collaborative roles of these proteins in pathogenesis. In this lecture, Dr. Saphire will illustrate the molecular function throughout the viral life cycle: how the Ebola virus glycoprotein remodels itself during viral entry and how this remodeling affects the antibody response; how the Ebola and Lassa viruses suppress host innate immune signaling; and how the Ebola matrix protein assembles into one structure to bud new virions and into a different conformation to bind RNA and control transcription inside infected cells. For more information go to wals.od.nih.gov Author: Erica Ollmann Saphire, Ph.D., Professor, Department of Immunology and Microbial Science, The Scripps Research Institute Runtime: Permanent link: videocast.nih.gov/launch.asp?18151Why it's here
From a health institutionNIH VideoCast is on Rounds' list of health institutions, and this upload is one of its most-watched lectures or explainers. Nobody has recommended it in the communities yet, so it ranks below community picks.