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The IGF-1 Trade-Off: Performance vs. Longevity

FoundMyFitness

736K subscribers • 6 videos on Rounds

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  • Recommended by 1 person, in Hacker News.
  • May be out of date. Uploaded 13 years ago, in an area where guidance changes.
  • Debated among experts. Its central claim is contested, so look for the other side.

Assumes interest and some biology. Education, not medical advice.

516K views13 years ago1 recommendation

Aging and longevityHeart and metabolismLongevity interventionsBiology of agingMetabolism and energy

An explanation of how growth hormone and IGF-1 promote muscle and cognitive performance but may negatively impact lifespan and stress resistance.

There is a tradeoff when it comes to growth hormone and IGF-1. Growth hormone and IGF-1 enhance muscle and cognitive performance but this comes at a cost: longevity. Reduced growth hormone and IGF-1 increase lifespan by increasing the expression of genes involved in stress resistance but at an expensive cost when it comes to muscles and brain. Learn all about the trade-off and ways to circumvent it. Links related to FoundMyFitness: ▶︎ Subscribe on YouTube: youtube.com/user/FoundMyFitness?sub_confirmation=1 ▶︎ Join my weekly email newsletter: foundmyfitness.com/?sendme=lifestyle-heuristic ▶︎ FoundMyFitness Genetics: foundmyfitness.com/genetics ▶︎ Crowdfund more videos: foundmyfitness.com/crowdsponsor ▶︎ Subscribe to the podcast: itunes.apple.com/us/podcast/foundmyfitness/id818198322 ▶︎ Twitter: twitter.com/foundmyfitness ▶︎ Facebook: facebook.com/foundmyfitness ▶︎ Instagram: instagram.com/foundmyfitness About FoundMyFitness: Rhonda Patrick has a Ph.D. in biomedical science from the University of Tennessee Health Science Center, and St. Jude Children’s Research Hospital. She also has a Bachelor’s of Science degree in biochemistry/chemistry from the University of California, San Diego. She has done extensive research on aging, cancer, and nutrition. It is Dr. Patrick’s goal to challenge the status quo and encourage the wider public to think about health and longevity using a proactive, preventative approach. Learn more about Dr. Rhonda Patrick and her mission for FoundMyFitness at www.foundmyfitness.com #IGF1 #growthhormone #lifespan

Why it's here

1 person recommends this

What people say. Recommended for its explanation of the biological trade-offs of growth hormone and IGF-1 on aging and performance.

dpatrick86in Hacker News • Recommends

On “What will it take to run a 2-hour marathon?”

Speaking to your question about "what the long term effects of these drugs are": My wife put together a together a pretty interesting video about the "faustian bargain" which is IGF-1 (used as a proxy measure for growth hormone)... video is replete with examples of the effects of low IGF-1/GH or high IGF-1/GH both in animal models and humans. One of the more interesting points in the video is the fact that people with polymorphisms that make their IGF-1 receptor experience some slight loss of function actually live longer (in general). link to this video The video also links to an article which has a bibliography if you're interested.
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femiagbabiakain Hacker News • Mentions

On “For 2M years, humans ate meat and little else: study”

1. Bigger groups === more and better data. I didn't know anyone growing up who was interested in ketogenic or carnivorous diets, now it's much more common. 2. Huge difference between the diet of a westerner following carnivore and traditional tribal carnivorous diets 3. The Inuits weren't particularly healthy, I'm not sure why their diet matters: link 4. And most importantly, there's a lot of research showing that high levels of IGF-1 associated with diets high in red meat are not good for longevity: link to this video
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loudtieblahblahin Hacker News • Mentions

On “Could cancer cells’ iron addiction be their Achilles heel?”

link link Its pretty well know mtor/igf-1 stimulates growth. All growth. This is great for youth. Not so much for aging. link to this video
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