Depression (Episode 3 of 4) — Advanced Treatments for Treatment-Resistant Depression | NEJM

Drs. Sanacora, Nikayin, and Cristancho discuss neuroplasticity and advanced therapies for treatment-resistant depression, including ECT, TMS, ketamine, and psilocybin.

In this third episode of a four-part Double Take video miniseries on depression from the New England Journal of Medicine, Drs. Sanacora, Nikayin, and Cristancho discuss the role neuroplasticity may play in the pathogenesis of depression and the benefits to patients of advanced therapies for treatment-resistant depression, such as electroconvulsive therapy and transcranial magnetic stimulation. An overview of emerging evidence for the use of ketamine, esketamine, and psilocybin as new or potential treatments is also examined. For further reading, the following articles, referenced in this video, are available at the Journal’s website: Esketamine for Treatment-Resistant Depression — First FDA-Approved Antidepressant in a New Class (Kim et al., in the July 4, 2019, issue; nejm.org/doi/full/10.1056/NEJMp1903305 ), Electroconvulsive Therapy (Espinoza and Kellner, in the February 17, 2022, issue; nejm.org/doi/full/10.1056/NEJMra2034954 ), Psilocybin in Treatment-Resistant Depression (Madras; nejm.org/doi/full/10.1056/NEJMe2210975 ) and Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression (Goodwin et al.; nejm.org/doi/full/10.1056/NEJMoa2206443 ) (both in the November 3, 2022, issue), Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression (Anand et al., in the June 22, 2023, issue; nejm.org/doi/full/10.1056/NEJMoa2302399 ), and Esketamine Nasal Spray versus Quetiapine for Treatment -Resistant Depression (Reif et al., in the October 5, 2023, issue; nejm.org/doi/full/10.1056/NEJMoa2304145 ). #depression #depressionmanagement #mentalhealth #mentalillness #nejm The _New England Journal of Medicine_ is the world’s leading general medical journal. Continuously published for over 200 years, the _Journal_ publishes peer-reviewed research along with interactive clinical content for physicians, educators, and the global medical community at NEJM.org.